LrgpV1, Main, Exploration, bibRecord, 000071

Modulation of singlet oxygen generation and amphiphilic properties of trihydroxylated monohalogenated porphyrins

Identifieur interne : 000071 ( Main/Exploration ); précédent : 000070; suivant : 000072

Modulation of singlet oxygen generation and amphiphilic properties of trihydroxylated monohalogenated porphyrins

Auteurs : Derya Topkaya ; Philippe Arnoux [France] ; Fabienne Dumoulin

Source :

Journal of Porphyrins and Phthalocyanines [ 1088-4246 ] ; 2015-10.

RBID : Hal:hal-01278689

Abstract

Two of the properties important for photodynamic therapy applications are systematically investigated on a trihydroxylated monohalogenated porphyrin core. Singlet oxygen generation can be increased thanks to the heavy atom effect, frequently provided by the introduction of halogen atoms on the photosensitizer. We compare the effect of the presence of the four halogen atoms with the analogous halogen-free porphyrin. Cell uptake is crucial as well for successful photodynamic outcome and is directly related to the amphiphilicity of the molecule. The five derivatives bearing H, F, Cl, Br or I atoms are compared in this regard. The presence of iodine atom induces a sharp difference in singlet oxygen generation compared to all the other derivatives investigated, but increases its lipophilicity, still in the limits suitable for biomedical applications.

Url:

https://hal.univ-lorraine.fr/hal-01278689

DOI: 10.1142/S1088424615500893

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000780
to stream Hal, to step Curation: 000780
to stream Hal, to step Checkpoint: 000058
to stream Main, to step Merge: 000071
to stream Main, to step Curation: 000071

Le document en format XML

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Modulation of singlet oxygen generation and amphiphilic properties of trihydroxylated monohalogenated porphyrins

Modulation of singlet oxygen generation and amphiphilic properties of trihydroxylated monohalogenated porphyrins

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri